abstract：:Thrombocytopenia is a common finding in cancer patients and can have different and/or multifactorial pathogenesis. While in solid tumors it occurs often as a consequence of chemotherapy treatment, it is frequently observed at diagnosis in patients with hematological malignancies being aggravated to a potentially life-...

journal_title：Thrombosis research

authors： Castaman G,Pieri L

更新日期：2018-04-01 00:00:00

abstract：:Cancer-associated arterial thrombotic events (ATEs) are increasingly recognized in specific malignancies and in association with the expanding armamentarium of novel chemotherapeutic agents. The improved cancer survival led to cardiovascular complications becoming clinically relevant many years after cancer diagnosis....

journal_title：Thrombosis research

authors： Aronson D,Brenner B

更新日期：2018-04-01 00:00:00

abstract：:Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although previous studies have suggested that the use of parenteral thromboprophylaxis in all ambulatory cancer patients receiving chemotherapy significantly decreases t...

journal_title：Thrombosis research

authors： Kimpton M,Wells PS,Carrier M

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Portal vein thrombosis (PVT) is a well-known complication in patients with liver cirrhosis (LC). The aim of this study is to investigate the outcomes of cirrhotic patients with PVT treated with low-molecular-weight heparin (LMWH). METHOD:Ninety-one LC patients with PVT were treated with dalteparin or enox...

journal_title：Thrombosis research

authors： Kwon J,Koh Y,Yu SJ,Yoon JH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Non-vitamin K antagonist oral anticoagulants (NOACs) do not need routine laboratory monitoring but measurement of drug concentration is important in emergency conditions. Specific laboratory tests are not readily available or not implemented in every hospital. Point-of-Care Tests (POCT) may bridge this gap a...

journal_title：Thrombosis research

authors： Padayattil Jose S,Banzato A,Carraro P,Haleh A,Rossi K,Nante G,Denas G,Zoppellaro G,Pengo V

更新日期：2018-03-01 00:00:00

abstract：:In spite of numerous studies on the involvement of fibrinogen in transendothelial migration of leukocytes and thereby inflammation, there is still no clear understanding of which fibrin(ogen) species can stimulate leukocyte transmigration. Although we have previously proposed that interaction of fibrin with the VLDL r...

journal_title：Thrombosis research

authors： Yakovlev S,Medved L

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Peripheral pulmonary artery thrombus (PPT) is common in the clinic. However, due to the lack of an ideal diagnostic tool, PPT cannot be quickly diagnosed and effectively treated at present. Optical coherence tomography (OCT) is a new intravascular imaging technique that is characterized by high image resolut...

journal_title：Thrombosis research

authors： Hong C,Luo FQ,Liu CL,Zhong NS,Li JY,Wang W

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

journal_title：Thrombosis research

authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thromb...

journal_title：Thrombosis research

authors： Nuytemans K,Ortel TL,Gomez L,Hofmann N,Alves N,Dueker N,Beecham A,Whitehead P,Hahn Estabrooks S,Kitchens CS,Erkan D,Brandão LR,James AH,Kulkarni R,Manco-Johnson MJ,Pericak-Vance MA,Vance JM

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Extracellular histones are reported to increase thrombin generation in the plasma and induce endothelial cell death in vitro. These effects of histones were suggested to involve histone-induced inhibition of TM-dependent activated protein C (APC) generation. Therefore, we hypothesized that TM alfa, a recom...

journal_title：Thrombosis research

authors： Osada K,Minami T,Arioka T,Sakai T,Tawara S,Kawasaki K,Fareed J,Matsuzaki O

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Whether clinical prediction rules for pulmonary embolism are accepted and used among general internal medicine residents remains uncertain. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which fa...

journal_title：Thrombosis research

authors： Faller N,Stalder O,Limacher A,Bassetti S,Beer JH,Genné D,Battegay E,Hayoz D,Leuppi J,Mueller B,Perrier A,Waeber G,Rodondi N,Aujesky D

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultat...

journal_title：Thrombosis research

authors： Skeith L,Mohamed M,Karovitch A,Liddy C,Afkham A,Archibald D,Keely E

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were in...

journal_title：Thrombosis research

authors： Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto P

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:In-vitro and in-vivo models suggest the influence of low-molecular weight heparin on conception in infertile women undergoing in vitro fertilization procedures (IVF). In this randomized controlled trial we assessed whether a low-molecular weight heparin (parnaparin) could affect IVF outcomes. MATERIALS AN...

journal_title：Thrombosis research

authors： Lodigiani C,Dentali F,Banfi E,Ferrazzi P,Librè L,Quaglia I,Cafaro L,Morenghi E,Pacetti V,Zannoni E,Baggiani AM,Levi-Setti PE

更新日期：2017-11-01 00:00:00

abstract：:Practice variation, the differences in clinical management between physicians, is one reason why patient outcomes may differ. Identifying factors that contribute to practice variation in areas of clinical uncertainty or equipoise may have implications for understanding and improving patient care. To discern what facto...

journal_title：Thrombosis research

authors： Skeith L,Gonsalves C

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Thrombosis and complement activation are pathogenic features of antiphospholipid syndrome (APS). Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from...

journal_title：Thrombosis research

authors： Grosso G,Vikerfors A,Woodhams B,Adam M,Bremme K,Holmström M,Ågren A,Eelde A,Bruzelius M,Svenungsson E,Antovic A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS:Patients with newly diagnosed cancer ...

journal_title：Thrombosis research

authors： El-Refai SM,Black EP,Adams VR,Talbert JC,Brown JD

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:The activated partial thromboplastin time (APTT) is commonly used to monitor unfractionated heparin (UFH) but may not accurately measure the amount of heparin present. The anti-Xa assay is less susceptible to confounding factors and may be a better assay for this purpose. MATERIALS AND METHODS:The validit...

journal_title：Thrombosis research

authors： Arachchillage DRJ,Kamani F,Deplano S,Banya W,Laffan M

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:The safety and efficacy of low-molecular-weight heparin (LMWH) treatment in patients with cancer-associated thrombosis (CAT) beyond 6months are unknown. Our aim was to determine the safety of long-term tinzaparin use in patients with CAT. METHODS:We performed a prospective, open, single arm, multicentre s...

journal_title：Thrombosis research

authors： Jara-Palomares L,Solier-Lopez A,Elias-Hernandez T,Asensio-Cruz M,Blasco-Esquivias I,Marin-Barrera L,de la Borbolla-Artacho MR,Praena-Fernandez JM,Montero-Romero E,Navarro-Herrero S,Serrano-Gotarredona MP,Sánchez-Díaz JM,Palacios

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis, which begins during the first trimester, but the exact time of onset is unknown. Thrombin generation, a laboratory marker of thrombosis risk, increases during normal pregnancy but it is unclear exactly how early this...

journal_title：Thrombosis research

authors： Bagot CN,Leishman E,Onyiaodike CC,Jordan F,Freeman DJ

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Even though thrombocytopenia following transcatheter aortic valve implantation (TAVI) has been described, further investigation of this phenomenon is needed. AIMS:To determine which factors may explain the fall in platelet count that occurs after implantation of a TAVI device, including markers of platele...

journal_title：Thrombosis research

authors： Mitrosz M,Kazimierczyk R,Sobkowicz B,Waszkiewicz E,Kralisz P,Frank M,Piszcz J,Galar M,Dobrzycki S,Musial WJ,Hirnle T,Kaminski KA,Tycinska AM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Despite treatment, women with von Willebrand disease (VWD) have lower von Willebrand factor (VWF) levels and greater blood loss at delivery than controls. Current weight-based dosing does not account for the ~1.5-fold increase in blood volume in pregnancy. METHODS:To evaluate the feasibility of a trial to p...

journal_title：Thrombosis research

authors： Ragni MV,Machin N,James AH,Seaman CD,Malec LM,Kessler CM,Konkle BA,Kouides PA,Neff AT,Philipp CS,Brooks MM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Upon platelet stimulation with agonists, reactive oxygen species (ROS) generation enhances platelet activation and granule release. Whether ROS generation during platelet storage could be directly correlated with the expression of proinflammatory molecules and granule release has been investigated in this st...

journal_title：Thrombosis research

authors： Ghasemzadeh M,Hosseini E

更新日期：2017-08-01 00:00:00

abstract：:Despite clear potential benefits of outpatient care, most patients suffering from pulmonary embolism (PE) are currently hospitalized due to the fear of possible adverse events. Nevertheless, some teams have increased or envisage to increase outpatient treatment or early discharge. We performed a narrative systematic r...

journal_title：Thrombosis research

authors： Roy PM,Moumneh T,Penaloza A,Sanchez O

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aime...

journal_title：Thrombosis research

authors： Stavik B,Holm S,Espada S,Iversen N,Sporsheim B,Bjerkeli V,Dahl TB,Sandset PM,Skjelland M,Espevik T,Skretting G,Halvorsen B

更新日期：2017-07-01 00:00:00

abstract：:18F-Fluorodesoxyglucose Positron-Emission-Tomography combined with Computed-Tomography (FDG PET/CT) might be an attractive tool for cancer screening in patients with venous thromboembolism (VTE), allowing non-invasive whole-body imaging. One of the frequent criticisms to the use of FDG PET/CT for screening is the pote...

journal_title：Thrombosis research

authors： Robin P,Le Roux PY,Le Moigne E,Planquette B,Prévot-Bitot N,Roy PM,Pastre J,Merah A,Couturaud F,Le Gal G,Salaun PY

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and inc...

journal_title：Thrombosis research

authors： Pike MM,Larson NB,Wassel CL,Cohoon KP,Tsai MY,Pankow JS,Hanson NQ,Decker PA,Berardi C,Alexander KS,Cushman M,Zakai NA,Bielinski SJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:A recent study suggested that the plasminogen activator inhibitor (PAI)-1 4G/5G genotype may play a role in the resolution of deep vein thrombosis (DVT) after surgery. In the present study, we investigated the association between PAI-1 4G/5G genotype and the persistence of venous occlusion after acute idiopa...

journal_title：Thrombosis research

authors： Giurgea GA,Brunner-Ziegler S,Jilma B,Sunder-Plassmann R,Koppensteiner R,Gremmel T

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS:In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had be...

journal_title：Thrombosis research

authors： Prandoni P,Ageno W,Mumoli N,Zanatta N,Imberti D,Visonà A,Ciammaichella M,Simioni L,Cappelli R,Bucherini E,Di Nisio M,Avruscio G,Camporese G,Parisi R,Cuppini S,Turatti G,Noventa F,Sarolo L

更新日期：2017-05-01 00:00:00

abstract：:Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss (MBL) >80 mL per cycle, that interferes with a woman's physical, emotional, social wellbeing and quality of life. Aetiology is due to underlying uterine pathologies, coagulopathy, ovulation dysfunction, or iatrogenic. Up to 20% of women with H...

journal_title：Thrombosis research

authors： Davies J,Kadir RA

更新日期：2017-03-01 00:00:00

abstract：:Activation of the coagulation and inflammatory systems are physiologically occurring during pregnancy. However, excess activation of either system is well documented in gestational vascular diseases (GVD). GVD are placenta-mediated pregnancy complications and a major cause of feto-maternal morbidity and mortality. The...

journal_title：Thrombosis research

authors： Kohli S,Isermann B

更新日期：2017-03-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...

journal_title：Thrombosis research

authors： Ende-Verhaar YM,Huisman MV,Klok FA

更新日期：2017-03-01 00:00:00

abstract：IMPORTANCE:Unprovoked venous thromboembolism (VTE) can be the first manifestation of cancer. It is unclear if extensive screening for occult cancer including a comprehensive computed tomography (CT) scan of the abdomen/pelvis is cost-effective in this patient population. OBJECTIVE:To assess the health care related cos...

journal_title：Thrombosis research

authors： Coyle K,Carrier M,Lazo-Langner A,Shivakumar S,Zarychanski R,Tagalakis V,Solymoss S,Routhier N,Douketis J,Coyle D

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:In the pathogenesis of sepsis-induced acute lung injury (ALI), the crosstalk between inflammation and coagulation plays a pivotal role. The aim of this study was to investigate the role of Rho kinase (ROCK) inhibitor in alleviating pulmonary inflammation and coagulation in lipopolysaccharide (LPS)-induced ...

journal_title：Thrombosis research

authors： Ding R,Zhao D,Li X,Liu B,Ma X

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patien...

journal_title：Thrombosis research

authors： Beyer-Westendorf J,Lensing AW,Arya R,Bounameaux H,Cohen AT,Wells PS,Middeldorp S,Verhamme P,Hughes R,Kucher N,Pap AF,Trajanovic M,Prins MH,Prandoni P,Weitz JI

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:Patients with intracerebral hemorrhage during rivaroxaban treatment have small hematoma and favorable outcomes compared with those with warfarin. We investigated its possible mechanism, focusing on prothrombin fragment 1+2 (F1+2), a marker of thrombin generation. MATERIALS AND METHODS:In 65 patients with ...

journal_title：Thrombosis research

authors： Hagii J,Tomita H,Metoki N,Tamai Y,Saito S,Shiroto H,Hitomi H,Kamada T,Seino S,Takahashi K,Sasaki S,Yasujima M,Okumura K

更新日期：2016-12-01 00:00:00

abstract：:Chronic immune thrombocytopenia purpura (ITP) is an autoimmune disease that exhibits an abnormally high Th1/Th2 ratio. Granulocyte colony-stimulating factor (G-CSF) has been shown to decrease the Th1/Th2 ratio in healthy donors. In this study, we investigated the effects of G-CSF treatment on the Th1/Th2 cells and the...

journal_title：Thrombosis research

authors： Ge F,Zhang Z,Hou J,Cao F,Zhang Y,Wang P,Wei H,Zhou J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Predictors of venous thromboembolism (VTE) after trauma are uncertain. OBJECTIVE:To identify independent predictors of VTE after acute trauma. METHODS:Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE within 92days a...

journal_title：Thrombosis research

authors： Park MS,Perkins SE,Spears GM,Ashrani AA,Leibson CL,Boos CM,Harmsen WS,Jenkins DH,Bailey KR,Ballman KV,Heit JA

更新日期：2016-08-01 00:00:00

abstract：:Activated platelets secrete different chemokines, among others CCL5, thereby triggering inflammatory cell recruitment into the vessel wall. Here, we investigated how CCL5 deficiency influences vascular remodeling processes. Experiments were performed in apolipoprotein E and CCL5 double deficient (ApoE(-/-)×CCL5(-/-)) ...

journal_title：Thrombosis research

authors： Czepluch FS,Meier J,Binder C,Hasenfuss G,Schäfer K

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Inherited abnormalities of fibrinogen (FG) are rare coagulation disorders divided into two types: quantitative abnormalities (afibrinogenemia and hypofibrinogenemia) or qualitative abnormalities (dysfibrinogenemia and hypo-dysfibrinogenemia) of circulating fibrinogen. In particular, congenital afibrinogene...

journal_title：Thrombosis research

authors： Amri Y,Toumi Nel H,Hadj Fredj S,de Moerloose P

更新日期：2016-07-01 00:00:00